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Structure of 401590-41-8
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6-Chloro-3-(trifluoromethyl)picolinonitrile features a trifluoromethyl group and a chlorine substituent positioned ortho to the nitrile on a pyridine core. This electron-deficient heterocycle integrates readily into cross-coupling reactions, offering high stability under standard conditions. The nitrile moiety enables further functionalization, while the fluorinated side chain enhances metabolic resistance in bioactive molecule design.
6-Chloro-3-(trifluoromethyl)picolinonitrile serves as a versatile building block in heterocyclic synthesis, enabling efficient access to functionalized pyridine scaffolds. The nitrile and trifluoromethyl groups provide orthogonal reactivity for downstream transformations, while the chloro substituent facilitates palladium-catalyzed cross-coupling reactions. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for medicinal chemistry campaigns and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: