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Structure of 400-75-9
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1-Iodo-4-nitro-2-(trifluoromethyl)benzene features a trifluoromethyl group and a nitro substituent positioned ortho to the iodine handle, creating a highly electron-deficient aromatic scaffold. This combination enables efficient palladium-catalyzed cross-coupling reactions under standard conditions, with the iodo moiety serving as a reactive anchor for C–C bond formation. The molecule exhibits bench-stable handling characteristics and moisture tolerance, facilitating integration into multi-step synthetic sequences for advanced pharmaceutical intermediates and functional materials.
1-Iodo-4-nitro-2-(trifluoromethyl)benzene serves as a versatile building block in cross-coupling reactions, enabling efficient construction of biaryl architectures under palladium catalysis. The iodide group facilitates reliable C–C bond formation, while the nitro and trifluoromethyl functionalities provide strong electron-withdrawing character and orthogonal reactivity for downstream functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for medicinal chemistry and materials synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H315-H319-H332-H335
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Precautionary Statements : P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: