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CS-W001157 4
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Methyl 6-(hydroxymethyl)picolinate

  • CAS No. 39977-44-1

  • Cat. No. CS-W013238
  • Purity≥96%
  • MDL No.MFCD03840850

*For research and further manufacturing use only, not for direct human use.

Methyl 6-(hydroxymethyl)picolinate|CS-W013238

Structure of 39977-44-1

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General Information

  • CAS No. 39977-44-1
  • Cat. No. CS-W013238
  • Purity ≥96%
  • MDL No. MFCD03840850
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₃
  • Molecular Weight 167.16
  • Synonym(s) METHYL-6-HYDROXYMETHYL-2-PYRIDINE-CARBOXYLATE
  • SMILES O=C(OC)C1=NC(CO)=CC=C1

Description

Methyl 6-(hydroxymethyl)picolinate features a pyridine ring bearing a methyl ester and a pendant hydroxymethyl group at the 6-position. This functionalized heterocycle integrates readily into synthetic sequences requiring polar, oxygen-rich motifs. The hydroxymethyl moiety enables further derivatization while maintaining solubility and stability under standard conditions.

Synthesis

  • Route1

    References

    • GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley Patent: WO2013/102145 A1, 2013 ; Location in patent: Paragraph 0333 ;
  • Route2
    • null|null
      363593-99-1
    • ~52%
    • In-stock
      Methyl 6-(hydroxymethyl)picolinate|CS-W013238
      39977-44-1

    References

    • BRISTOL-MYERS SQUIBB COMPANY Patent: WO2009/152082 A1, 2009 ; Location in patent: Page/Page column 213 ; WO 2009/152082 A1
  • Route3

    References

    • Jew, Sang-Sup; Park, Boon-Saeng; Lim, Doo-Yeon; Kim, Myoung Goo; Chung, In Kwon; Kim, Joo Hee; Hong, Chung Il; Kim, Joon-Kyum; Park, Hong-Jun; Lee, Jun-Hee; Park, Hyeung-Geun Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 609 - 612

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   0.3605
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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