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CS-W001157 4
Total: USD 88.00

6-Chloro-3-pyridineacetic acid

  • CAS No. 39891-13-9

  • Cat. No. CS-W001177
  • Purity≥98%
  • MDL No.MFCD01863172

*For research and further manufacturing use only, not for direct human use.

6-Chloro-3-pyridineacetic acid|CS-W001177

Structure of 39891-13-9

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General Information

  • CAS No. 39891-13-9
  • Cat. No. CS-W001177
  • Purity ≥98%
  • MDL No. MFCD01863172
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₂
  • Molecular Weight 171.58
  • Synonym(s) None
  • SMILES O=C(CC1=CN=C(C=C1)Cl)O

Description

2-Chloropyridine-5-acetic acid features a chlorinated pyridine core paired with a carboxylic acid group, enabling versatile conjugation and functionalization. This arrangement delivers enhanced solubility and reactivity under standard conditions, supporting efficient integration into pharmaceutical intermediates and bioconjugation workflows.

Application

2-Chloropyridine-5-acetic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient functionalization at the pyridine ring and carboxylic acid terminus. Its chlorine substituent facilitates nucleophilic substitution reactions, while the pendant acetic acid group offers direct conjugation or derivatization potential. The compound exhibits good bench stability and compatibility with standard coupling protocols, supporting its use in medicinal chemistry and API intermediate development.

Synthesis

  • Route1

    References

    • DOW AGROSCIENCES LLC Patent: WO2004/57960 A2, 2004 ; Location in patent: Page 16-17 ;
  • Route2

    References

    • Holla, B. Shivarama; Prasanna; Poojary, Boja; Rao; Shridhara; Bhat, U. Ganesha Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 4 p. 864 - 868

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.3621
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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