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CS-W001157 4
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5-Amino-2-methylpyrimidine

  • CAS No. 39889-94-6

  • Cat. No. CS-W018646
  • Purity≥96%
  • MDL No.MFCD09608109

*For research and further manufacturing use only, not for direct human use.

5-Amino-2-methylpyrimidine|CS-W018646

Structure of 39889-94-6

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General Information

  • CAS No. 39889-94-6
  • Cat. No. CS-W018646
  • Purity ≥96%
  • MDL No. MFCD09608109
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃
  • Molecular Weight None
  • Synonym(s) 5-Pyrimidinamine, 2-methyl- (9CI)
  • SMILES C1=NC(=NC=C1N)C

Description

5-Amino-2-methylpyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, offering a tunable platform for bioactive compound synthesis. The amino and methyl groups enable strategic functionalization, while the pyrimidine core provides metabolic stability and favorable pharmacokinetic properties in drug discovery applications.

Application

5-Amino-2-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its amino and methyl groups provide orthogonal functional handles for selective derivatization, including amidation, alkylation, and transition-metal-catalyzed coupling reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns targeting kinase inhibitors and antiviral agents.

Synthesis

  • Route1
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      1384878-34-5
    • ~%
    • In-stock
      5-Amino-2-methylpyrimidine|CS-W018646
      39889-94-6

    References

    • VIVALIS; CIAPETTI, Paola; TROUCHE, Nathalie; VENKATA PITHANI, Subhash; GUEDAT, Philippe; BERECIBAR, Amaya Patent: WO2012/93174 A1, 2012 ; Location in patent: Page/Page column 57 ; WO 2012/093174 A1
  • Route2
    • null|null
      84610-03-7
    • ~82%
    • In-stock
      5-Amino-2-methylpyrimidine|CS-W018646
      39889-94-6

    References

    • Mikhaleva, M. A.; Lazareva, V. T.; Grebenkin, M.F.; Savel'ev, V. A.; Mamaev, V. P. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 11 p. 1201 - 1208 Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 11 p. 1545 - 1552
  • Route3

    References

    • Urban; Schnider Helvetica Chimica Acta, 1958 , vol. 41, p. 1806,1812

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.36722
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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