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Structure of 398-62-9
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4-Fluoro-1,2-dimethoxybenzene features a fluorine atom at the para position relative to a 1,2-dimethoxy substitution pattern, delivering enhanced electron-withdrawing character and improved metabolic stability. This combination enables efficient incorporation into complex aromatic scaffolds during late-stage functionalization and transition-metal-catalyzed coupling reactions under standard conditions.
4-Fluoro-1,2-dimethoxybenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient Suzuki-Miyaura and Buchwald-Hartwig coupling reactions. The ortho-dimethoxy substitution pattern enhances regioselectivity in electrophilic functionalization, while the fluorine substituent provides favorable electronic modulation and metabolic stability. Its bench-stable nature and compatibility with standard reaction conditions facilitate streamlined purification and scale-up.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H227-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: