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CS-W001157 4
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5-Fluoro-2-methoxyphenol

  • CAS No. 72955-97-6

  • Cat. No. CS-W002426
  • Purity≥98%
  • MDL No.MFCD00143459

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-methoxyphenol|CS-W002426

Structure of 72955-97-6

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General Information

  • CAS No. 72955-97-6
  • Cat. No. CS-W002426
  • Purity ≥98%
  • MDL No. MFCD00143459
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FO₂
  • Molecular Weight 142.13
  • Synonym(s) 5-fluoro-2-metoxyphenol
  • SMILES COc1ccc(cc1O)F

Description

5-Fluoro-2-methoxyphenol features a fluorinated aromatic ring paired with a methoxy group, delivering enhanced electronic modulation and metabolic stability. This combination enables precise tuning of reactivity in synthetic intermediates, particularly within pharmaceutical and agrochemical development workflows. The compound exhibits robust bench stability and compatibility with standard reaction conditions.

Application

5-Fluoro-2-methoxyphenol serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds. Its ortho-difunctionalized structure—combining a phenolic OH and methoxy group—facilitates selective derivatization and coupling reactions. The molecule exhibits good bench stability and compatibility with standard protection/deprotection sequences, making it well-suited for multi-step synthesis workflows targeting bioactive heterocycles and API intermediates.

Synthesis

  • Route1

    References

    • Bulletin des Societes Chimiques Belges, , vol. 102, # 3 p. 217 - 226
  • Route2

    References

    • Audouze, Karine; Nielsen, Elsebet stergaard.; Peters, Dan Journal of Medicinal Chemistry, 2004 , vol. 47, # 12 p. 3089 - 3104
  • Route3
    • null|null
      126209-85-6
    • ~93%
    • In-stock
      5-Fluoro-2-methoxyphenol|CS-W002426
      72955-97-6

    References

    • Mancini, M. L.; Honek, J. F. Synthetic Communications, 1989 , vol. 19, # 11-12 p. 2001 - 2016

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.5399
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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