Lot numbers can be found on the outside label of a product:
1-Bromo-2-chloro-3-nitrobenzene
-
CAS No. 3970-37-4
- Cat. No. CS-W008709
- Purity≥98%
- MDL No.MFCD08277301
*For research and further manufacturing use only, not for direct human use.
Structure of 3970-37-4
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 3970-37-4
- Cat. No. CS-W008709
- Purity ≥98%
- MDL No. MFCD08277301
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₃BrClNO₂
- Molecular Weight 236.45
- Synonym(s) benzene, 1-bromo-2-chloro-3-nitro-
- SMILES O=[N+](C1=C(Cl)C(Br)=CC=C1)[O-]
Description
1-Bromo-2-chloro-3-nitrobenzene is a tri-substituted aromatic compound featuring bromo, chloro, and nitro groups in ortho and meta positions. This electron-deficient scaffold enables selective coupling reactions in cross-coupling protocols and serves as a key intermediate in pharmaceutical synthesis. The molecule exhibits enhanced stability under standard conditions and facilitates regioselective functionalization due to its distinct electronic profile.
Application
1-Bromo-2-chloro-3-nitrobenzene serves as a versatile building block in aromatic synthesis, enabling selective functionalization via palladium-catalyzed cross-coupling reactions. The ortho-halogen pattern facilitates sequential substitution with high regiocontrol, while the nitro group provides a handle for reduction or electrophilic transformation. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for constructing complex heterocyclic scaffolds and pharmaceutical intermediates.
Synthesis
-
Route1
-
3970-35-2 - ~93%
-
In-stock
3970-37-4
References
-
Vara Prasad; Boyer, Frederick E.; Chupak, Lou; Dermyer, Michael; Ding, Qizhu; Gavardinas; Hagen, Susan E.; Huband, Michael D.; Jiao, Wenhua; Kaneko, Takushi; Maiti, Samarendra N.; Melnick, Michael; Romero, Karina; Patterson; Wu, Xiujuan Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 20 p. 5392 - 5397
-
-
Route2
-
In-stock
59255-95-7 - ~%
-
In-stock
3970-37-4
References
-
GLAXO GROUP LIMITED; CHAMBERS, Laura Jane; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; STEADMAN, Jon Graham Anthony; WALTER, Daryl Simon Patent: WO2010/125103 A1, 2010 ; Location in patent: Page/Page column 78 ; WO 2010/125103 A1
-
-
Route3
-
In-stock
3970-41-0 - ~%
-
In-stock
3970-37-4
References
-
Takeda Pharmaceutical Company Limited Patent: EP1847541 A1, 2007 ; Location in patent: Page/Page column 71-72 ; EP 1847541 A1
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 43.14
- LogP 3.0107
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 1-Bromo-2-chloro-3-nitrobenzene sigma1-Bromo-2-chloro-3-nitrobenzene manufacturer1-Bromo-2-chloro-3-nitrobenzene price1-Bromo-2-chloro-3-nitrobenzene structure1-Bromo-2-chloro-3-nitrobenzene SDSbuy 1-Bromo-2-chloro-3-nitrobenzene1-Bromo-2-chloro-3-nitrobenzene supplier1-Bromo-2-chloro-3-nitrobenzene uses1-Bromo-2-chloro-3-nitrobenzene molecular weightprice of 1-Bromo-2-chloro-3-nitrobenzene1-Bromo-2-chloro-3-nitrobenzene chemical name formula of 1-Bromo-2-chloro-3-nitrobenzene