Lot numbers can be found on the outside label of a product:
(R)-2-Methoxy-2-phenylacetic acid
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CAS No. 3966-32-3
- Cat. No. CS-0020718
- Purity≥98%
- MDL No.MFCD00004250
*For research and further manufacturing use only, not for direct human use.
Structure of 3966-32-3
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General Information
- CAS No. 3966-32-3
- Cat. No. CS-0020718
- Purity ≥98%
- MDL No. MFCD00004250
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₁₀O₃
- Molecular Weight 166.17
- Synonym(s) (R)-α-Methoxybenzeneacetic acid
- SMILES CO[C@@H](C(O)=O)C1=CC=CC=C1
Description
(R)-2-Methoxy-2-phenylacetic acid is a chiral building block featuring a stereodefined α-methyl group and a methoxy-substituted benzylic center. This configuration enables selective incorporation into pharmaceutical intermediates, where the phenyl ring provides rigidity and the ester-like methoxy functionality supports further derivatization under mild conditions. The compound exhibits enhanced solubility in organic solvents and stability during standard bench handling.
Application
(R)-2-Methoxy-2-phenylacetic acid serves as a valuable chiral building block in asymmetric synthesis, enabling stereoselective transformations through its enantiomerically pure α-alkoxy-α-aryl motif. The molecule exhibits excellent bench stability and facilitates efficient derivatization via esterification, amidation, or metal-catalyzed coupling reactions. Its functional group tolerance supports downstream modifications in medicinal chemistry and process development workflows.
Synthesis
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Route1
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1260157-28-5 - ~90%
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In-stock
3966-32-3
References
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Senapati, Bidyut Kumar; Lee, Sungil; Ryu, Do Hyun; Hwang, Geum-Sook Angewandte Chemie, International Edition, 2009 , vol. 48, # 24 p. 4398 - 4401
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Route2
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121194-48-7
- ~90%
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In-stock
3966-32-3
References
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Takano, Seiichi; Yanase, Masashi; Ogasawara, Kunio Synthesis, 1989 , # 1 p. 39 - 40
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Route3
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In-stock
7021-09-2 - ~%
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In-stock
3966-32-3
References
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Nakamura, Shingo; Kaneeda, Masanobu; Ishihara, Kazuaki; Yamamoto, Hisashi Journal of the American Chemical Society, 2000 , vol. 122, # 34 p. 8120 - 8130
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Safety Information
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352
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Quality Control
Computational Chemistry Data
- TPSA 46.53
- LogP 1.4587
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 3
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Key Words
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