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CS-W001157 4
Total: USD 88.00

(S)-2-Methoxy-2-phenylacetic acid

  • CAS No. 26164-26-1

  • Cat. No. CS-0059225
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-2-Methoxy-2-phenylacetic acid|CS-0059225

Structure of 26164-26-1

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General Information

  • CAS No. 26164-26-1
  • Cat. No. CS-0059225
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₃
  • Molecular Weight 166.17
  • Synonym(s) benzeneacetic acid, alpha-methoxy-, ion(1-), (alphaS)-
  • SMILES O=C(O)[C@@H](OC)C1=CC=CC=C1

Description

Reactant involved in the synthesis of biologically active molecules including:Acyclonucleoside phosphonates structural analogs of adefovirLabeled discodermolide for studying binding to tubulin10-Isocyano-4-cadinene used for antifouling activityReactant involved in studies of immunostimulating chromanones gonytolides A-CReactant involved in: Hydroxylations and epoxidationsHydrogenations

Application

(S)-2-Methoxy-2-phenylacetic acid serves as a valuable chiral building block for synthesizing pharmaceutically relevant β-aryl-α-hydroxy acids and related scaffolds. Its stability under standard reaction conditions, combined with orthogonal functional group tolerance, enables reliable incorporation into complex molecules via esterification, amidation, or further derivatization. The defined stereochemistry facilitates asymmetric synthesis of bioactive compounds where enantiomeric purity is critical.

Synthesis

  • Route1
    • Methyl 2-methoxy-2-phenylacetate|CS-0663632
      3558-61-0
    • ~85%
    • In-stock
      (S)-2-Methoxy-2-phenylacetic acid|CS-0059225
      26164-26-1

    References

    • Organic Letters, , vol. 14, # 12 p. 3194 - 3197
  • Route2
    • In-stock
      (S)-Mandelic acid Atomoxetine Impurity|CS-0229548
      17199-29-0
    • null|null
      77-78-1
    • ~37%
    • In-stock
      (S)-2-Methoxy-2-phenylacetic acid|CS-0059225
      26164-26-1

    References

    • Journal of Medicinal Chemistry, , vol. 35, # 12 p. 2238 - 2243
  • Route3
    • (S)-2-Methoxy-2-phenylethanol|CS-0527581
      66051-01-2
    • ~79%
    • In-stock
      (S)-2-Methoxy-2-phenylacetic acid|CS-0059225
      26164-26-1

    References

    • Tetrahedron Asymmetry, , vol. 14, # 4 p. 503 - 510

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.4587
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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