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CS-W001157 4
Total: USD 88.00

Ethyl 2-methoxyacetate

  • CAS No. 3938-96-3

  • Cat. No. CS-0008463
  • Purity≥96%
  • MDL No.MFCD00009176

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-methoxyacetate|CS-0008463

Structure of 3938-96-3

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General Information

  • CAS No. 3938-96-3
  • Cat. No. CS-0008463
  • Purity ≥96%
  • MDL No. MFCD00009176
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀O₃
  • Molecular Weight 118.13
  • Synonym(s) Ethyl methoxyacetate; Methoxyacetic acid ethyl ester; Ethylmethoxyacetate,maycontainvariableamountsofethanol
  • SMILES O=C(OCC)COC

Description

Ethyl methoxyacetate was used:as acyl donor during the preparation of enantiomers of several phenylethylaminesas acylation reagent for the aminolysis of 1-phenylethanaminein an industrial, lipase-catalysed kinetic resolution of primary amine

Application

Ethyl 2-methoxyacetate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to α-alkylated esters and heterocyclic scaffolds. Its methoxy-substituted acetic acid backbone facilitates nucleophilic substitution and Claisen-type condensations under mild conditions. The compound exhibits excellent bench stability, ease of handling, and compatibility with diverse functional groups, making it ideal for iterative synthesis and scale-up applications in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      64-17-5
    • In-stock
      Methoxyacetic acid|CS-W020123
      625-45-6
    • ~65%
    • In-stock
      Ethyl 2-methoxyacetate|CS-0008463
      3938-96-3

    References

    • WAKO PURE CHEMICAL INDUSTRIES, LTD. Patent: US2010/324314 A1, 2010 ; Location in patent: Page/Page column 16 ;
  • Route2
    • null|null
      623-73-4
    • null|null
      67-56-1
    • ~90%
    • In-stock
      Ethyl 2-methoxyacetate|CS-0008463
      3938-96-3

    References

    • Zhu, Zuolin; Espenson, James H. Journal of the American Chemical Society, 1996 , vol. 118, # 41 p. 9901 - 9907
  • Route3
    • null|null
      64-17-5
    • In-stock
      Acetyl chloride, 2-methoxy-|CS-0022342
      38870-89-2
    • ~%
    • In-stock
      Ethyl 2-methoxyacetate|CS-0008463
      3938-96-3

    References

    • Van Waes, Frederik E. A.; Cukalovic, A.; Stevens, Christian V.; Drabowicz, J. Green Chemistry, 2012 , vol. 14, # 10 p. 2776 - 2779,4

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Warning
UN#: 3272
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   0.1959
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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