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Structure of 392-86-9
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2-Aminobenzene-1-sulfonyl fluoride delivers a reactive sulfonyl fluoride group flanked by an electron-rich amine, enabling selective conjugation in bioorthogonal labeling. This bench-stable reagent integrates efficiently into peptide and small-molecule scaffolds under mild conditions, offering robust coupling with nucleophilic residues.
2-Aminobenzene-1-sulfonyl fluoride serves as a versatile building block in medicinal chemistry, enabling direct introduction of a sulfonamide moiety with ortho-amino functionality. Its reactivity facilitates efficient amide coupling and nucleophilic substitution reactions, while the fluorosulfonyl group offers enhanced electrophilicity for targeted derivatization. Bench-stable and compatible with standard purification protocols, it functions effectively in the synthesis of bioactive heterocycles and protein-targeting scaffolds.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H290-H302-H314-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: