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Structure of 368-50-3
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3-Aminobenzenesulfonyl fluoride is a reactive sulfonyl fluoride reagent featuring an electron-rich aromatic amine group. This combination enables selective labeling and covalent modification of nucleophilic residues in proteins and biomolecules under physiological conditions. The molecule integrates seamlessly into probe design workflows, offering enhanced stability and controlled reactivity for chemical biology applications.
3-Aminobenzenesulfonyl fluoride serves as a versatile building block in medicinal chemistry, enabling the direct introduction of both sulfonamide and amine functionalities in a single step. Its reactivity facilitates efficient amide and sulfonamide couplings under mild conditions, with excellent bench stability and compatibility across diverse reaction matrices. The molecule functions as a key intermediate in the synthesis of heterocyclic scaffolds and targeted API candidates, particularly in kinase inhibitor development.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 3265
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302-H314-H332
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Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501
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Lot numbers can be found on the outside label of a product: