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CS-W001157 4
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2-(Boc-aminomethyl)phenol

  • CAS No. 390427-07-3

  • Cat. No. CS-0154385
  • Purity≥98%
  • MDL No.MFCD11655886

*For research and further manufacturing use only, not for direct human use.

2-(Boc-aminomethyl)phenol|CS-0154385

Structure of 390427-07-3

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General Information

  • CAS No. 390427-07-3
  • Cat. No. CS-0154385
  • Purity ≥98%
  • MDL No. MFCD11655886
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇NO₃
  • Molecular Weight 223.27
  • Synonym(s) tert-butyl 2-hydroxybenzylcarbamate
  • SMILES CC(C)(OC(NCC1=CC=CC=C1O)=O)C

Description

2-(Boc-aminomethyl)phenol features a protected amine tethered to a phenolic backbone, enabling seamless incorporation into peptide and small-molecule syntheses. The Boc group ensures stability during handling and reaction sequences, while the hydroxyl moiety offers a site for derivatization. This scaffold supports modular assembly in medicinal chemistry and combinatorial libraries.

Application

2-(Boc-aminomethyl)phenol serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. The Boc-protected amine enables orthogonal functional group manipulation, while the phenolic hydroxyl supports direct derivatization or metal-catalyzed coupling reactions. Its bench-stable nature and compatibility with standard deprotection protocols facilitate efficient multi-step synthesis in medicinal chemistry workflows.

Synthesis

  • Route1

    References

    • Lee, Chanhyo; Lee, Dong Hoon; Hong, Jong-In Tetrahedron Letters, 2001 , vol. 42, # 49 p. 8665 - 8668
  • Route2

    References

    • Lee, Chanhyo; Lee, Dong Hoon; Hong, Jong-In Tetrahedron Letters, 2001 , vol. 42, # 49 p. 8665 - 8668
  • Route3

    References

    • Lee, Chanhyo; Lee, Dong Hoon; Hong, Jong-In Tetrahedron Letters, 2001 , vol. 42, # 49 p. 8665 - 8668

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.56
  • LogP   2.4169
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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