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CS-W001157 4
Total: USD 88.00

(4-Chloropyrimidin-5-yl)methanol

  • CAS No. 389799-45-5

  • Cat. No. CS-0183167
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4-Chloropyrimidin-5-yl)methanol|CS-0183167

Structure of 389799-45-5

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General Information

  • CAS No. 389799-45-5
  • Cat. No. CS-0183167
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅ClN₂O
  • Molecular Weight 144.56
  • Synonym(s) 5-Pyrimidinemethanol, 4-chloro- (9CI)
  • SMILES C1=C(CO)C(=NC=N1)Cl

Description

(4-Chloropyrimidin-5-yl)methanol features a pyrimidine core bearing a chloro substituent at the 4-position and a primary alcohol at the 5-position. This combination enables direct functionalization in synthetic sequences, particularly in nucleophilic substitution reactions or as a linker for bioconjugation. The molecule exhibits good stability under standard bench conditions and facilitates integration into pharmaceutical intermediates and agrochemical scaffolds.

Application

(4-Chloropyrimidin-5-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its chloro group facilitates nucleophilic substitution reactions, while the pendant alcohol supports derivatization via esterification or ether formation. The compound exhibits good bench stability and is compatible with standard coupling protocols, making it well-suited for modular synthesis of kinase inhibitors and other bioactive heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   0.6223
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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