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CS-W001157 4
Total: USD 88.00

4-(4-Fluorophenyl)piperidin-4-ol

  • CAS No. 3888-65-1

  • Cat. No. CS-0207135
  • Purity≥98%
  • MDL No.MFCD00023146

*For research and further manufacturing use only, not for direct human use.

4-(4-Fluorophenyl)piperidin-4-ol|CS-0207135

Structure of 3888-65-1

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General Information

  • CAS No. 3888-65-1
  • Cat. No. CS-0207135
  • Purity ≥98%
  • MDL No. MFCD00023146
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₄FNO
  • Molecular Weight 195.23
  • Synonym(s) 4-(4-Fluorophenyl)-4-piperidinol
  • SMILES C1=C(C=CC(=C1)F)C2(CCNCC2)O

Synthesis

  • Route1
    • 1-Benzyl-4-(4-fluorophenyl)piperidin-4-ol|CS-0582784
      163631-02-5
    • ~82%
    • 4-(4-Fluorophenyl)piperidin-4-ol|CS-0207135
      3888-65-1

    References

    • NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A. Patent: WO2013/96744 A1, 2013 ; Location in patent: Page/Page column 213 ;
  • Route2
    • 1-Boc-4-(4-fluorophenyl)-4-hydroxypiperidine|CS-0210800
      553631-05-3
    • ~%
    • 4-(4-Fluorophenyl)piperidin-4-ol|CS-0207135
      3888-65-1

    References

    • Chen, Gang; Xia, Hongguang; Cai, Yu; Ma, Dawei; Yuan, Junying; Yuan, Chengye Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 234 - 239
  • Route3
    • Ethyl 4-(4-Fluorophenyl)-4-hydroxypiperidine-1-carboxylate|CS-0765389
      82387-58-4
    • ~89%
    • 4-(4-Fluorophenyl)piperidin-4-ol|CS-0207135
      3888-65-1

    References

    • Protiva; Kopicova; Grimova Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 2 p. 636 - 643

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H412
Precautionary Statements : P264-P273-P280-P302+P352-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   1.3967
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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