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3-Iodo-4-methylpyridine

  • CAS No. 38749-96-1

  • Cat. No. CS-0152933
  • Purity≥98%
  • MDL No.MFCD12828240

*For research and further manufacturing use only, not for direct human use.

3-Iodo-4-methylpyridine|CS-0152933

Structure of 38749-96-1

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General Information

  • CAS No. 38749-96-1
  • Cat. No. CS-0152933
  • Purity ≥98%
  • MDL No. MFCD12828240
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆IN
  • Molecular Weight 219.02
  • Synonym(s) Pyridine, 3-iodo-4-methyl- (9CI)
  • SMILES CC1=CC=NC=C1I

Description

3-Iodo-4-methylpyridine is a bench-stable, electron-deficient heterocycle featuring a para-substituted iodine and methyl group on the pyridine ring. This configuration enables direct coupling in cross-coupling reactions, facilitating efficient access to functionalized pyridyl architectures in medicinal chemistry and materials science.

Application

3-Iodo-4-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined reactivity at the iodine site. The 4-methyl group enhances electronic stability and facilitates downstream functionalization. Its bench-stable nature and compatibility with standard coupling protocols make it ideal for constructing complex heterocyclic scaffolds and pharmaceutical intermediates.

Synthesis

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    • In-stock
      3-Iodo-4-methylpyridine|CS-0152933
      38749-96-1
    • 3,5-Diiodo-4-methylpyridine|CS-0193463
      98139-01-6

    References

    • Plazek et al. Roczniki Chemii, 1952 , vol. 26, p. 106,108 Chem.Abstr., 1953 , p. 7497 Full Text Show Details Palat et al. Rozhledy TuberkuloseChem.Abstr., 1959 , vol. 19, p. 716,717 Rozhledy TuberkuloseChem.Abstr., 1960 , p. 11016

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.99462
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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