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Structure of 1870916-87-2
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Mc-Val-Ala-PAB is a peptide-based linker designed for site-specific conjugation in antibody-drug conjugates. This sequence integrates a maleimide-capped valine-alanine dipeptide with a para-aminobenzoyl (PAB) moiety, enabling efficient thiol-directed coupling and stable attachment to payload molecules under physiological conditions.
Mc-Val-Ala-PAB serves as a well-established linker module in antibody-drug conjugate (ADC) synthesis, enabling site-specific payload attachment via hydrazone bond formation. Its stability under physiological conditions and efficient cleavage in the acidic tumor microenvironment make it a reliable choice for controlled drug release. The sequence exhibits favorable solubility and bench stability, facilitating straightforward purification and integration into complex peptide architectures.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: