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Mc-​Val-​Ala-​PAB

  • CAS No. 1870916-87-2

  • Cat. No. CS-0103020
  • Molecule weight486.56
  • Purity≥97%
  • MDL No.MFCD32063500

*For research and further manufacturing use only, not for direct human use.

Mc-​Val-​Ala-​PAB|CS-0103020

Structure of 1870916-87-2

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General Information

  • CAS No. 1870916-87-2
  • Cat. No. CS-0103020
  • Purity ≥97%
  • MDL No. MFCD32063500
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₃₄N₄O₆
  • Molecular Weight 486.56
  • Synonym(s) Mc-Val-Ala-PAB
  • SMILES OCC1=CC=C(NC([C@H](C)NC([C@H](C(C)C)NC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O)C=C1

Description

Mc-Val-Ala-PAB is a peptide-based linker designed for site-specific conjugation in antibody-drug conjugates. This sequence integrates a maleimide-capped valine-alanine dipeptide with a para-aminobenzoyl (PAB) moiety, enabling efficient thiol-directed coupling and stable attachment to payload molecules under physiological conditions.

Application

Mc-Val-Ala-PAB serves as a well-established linker module in antibody-drug conjugate (ADC) synthesis, enabling site-specific payload attachment via hydrazone bond formation. Its stability under physiological conditions and efficient cleavage in the acidic tumor microenvironment make it a reliable choice for controlled drug release. The sequence exhibits favorable solubility and bench stability, facilitating straightforward purification and integration into complex peptide architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   144.91
  • LogP   1.2483
  • H_Acceptors   6
  • H_Donors   4
  • Rotatable_Bonds   13

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