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CS-W001157 4
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5-(Methylsulfonyl)indoline

  • CAS No. 387350-92-7

  • Cat. No. CS-0131088
  • Purity≥98%
  • MDL No.MFCD01319203

*For research and further manufacturing use only, not for direct human use.

5-(Methylsulfonyl)indoline|CS-0131088

Structure of 387350-92-7

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General Information

  • CAS No. 387350-92-7
  • Cat. No. CS-0131088
  • Purity ≥98%
  • MDL No. MFCD01319203
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₂S
  • Molecular Weight 197.25
  • Synonym(s) 5-methylsulfonyl-2,3-dihydro-1H-indole
  • SMILES O=S(C1=CC2=C(NCC2)C=C1)(C)=O

Description

5-(Methylsulfonyl)indoline features a sulfone-functionalized indoline scaffold, offering enhanced polarity and metabolic stability. This electron-deficient moiety integrates readily into bioactive molecule design, enabling efficient coupling in cross-coupling reactions under standard conditions. The methylsulfonyl group enhances solubility and resistance to oxidation, supporting robust performance in medicinal chemistry applications.

Application

5-(Methylsulfonyl)indoline serves as a versatile building block in medicinal chemistry, offering a stable, bench-ready scaffold with a polar methylsulfonyl group that enhances solubility and metabolic stability. It functions as a key intermediate in the synthesis of heterocyclic compounds, enabling efficient coupling reactions and serving as a core structure in bioactive molecule development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.17
  • LogP   1.0581
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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