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Structure of 386715-33-9
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This pyridine derivative features a chloromethyl group at the 5-position and a trifluoromethyl substituent at the 2-position, creating a uniquely reactive and electron-deficient scaffold. The trifluoromethyl moiety enhances metabolic stability and lipophilicity, while the pendant chloromethyl group enables facile nucleophilic substitution for conjugation or functionalization in synthetic workflows. This combination delivers a robust platform for medicinal chemistry and materials science applications.
5-(Chloromethyl)-2-(trifluoromethyl)pyridine serves as a versatile building block for C–H functionalization and cross-coupling reactions, enabling efficient access to substituted pyridine scaffolds. The chloromethyl group facilitates nucleophilic substitution under mild conditions, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity—key attributes in medicinal chemistry. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 3265
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302+H312+H332-H314
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Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P330+P331-P302+P352-P304+P340-P330-P362+P364-P363-P405-P501
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Lot numbers can be found on the outside label of a product: