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CS-W001157 4
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2-(((4-Methyl-1H-imidazol-5-yl)methyl)thio)ethanamine dihydrochloride

  • CAS No. 38603-72-4

  • Cat. No. CS-0153441
  • Purity≥97%
  • MDL No.MFCD12031495

*For research and further manufacturing use only, not for direct human use.

2-(((4-Methyl-1H-imidazol-5-yl)methyl)thio)ethanamine dihydrochloride|CS-0153441

Structure of 38603-72-4

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General Information

  • CAS No. 38603-72-4
  • Cat. No. CS-0153441
  • Purity ≥97%
  • MDL No. MFCD12031495
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅Cl₂N₃S
  • Molecular Weight 244.19
  • Synonym(s) 4-Methyl-5-[(2-aminoethyl)thiomethyl]imidazole Dihydrochloride
  • SMILES CC1=C(CSCCN)NC=N1.Cl.Cl

Description

l--phosphatidylcholine constitutes 20% of the total phospholipids in chicken egg. It has palmitic acid (16:0) and oleic acid (18:1) in at sn-1 and sn-2 positions, respectively.Egg PC (95%) has been used for the reconstitution of purified Kv1.3 into liposomes.

Application

2-(((4-Methyl-1H-imidazol-5-yl)methyl)thio)ethanamine dihydrochloride serves as a versatile building block in medicinal chemistry, enabling the construction of imidazole-containing scaffolds via standard amine coupling and alkylation reactions. The dihydrochloride salt enhances solubility and stability in aqueous media, facilitating handling and purification. Its thioether-linked imidazole functionality exhibits favorable functional group tolerance and compatibility with diverse reaction conditions common in peptide and small-molecule synthesis.

Synthesis

  • Route1

    References

    • Smith Kline and French Laboratories Limited Patent: US3954982 A1, 1976 ; US 3954982 A
  • Route2

    References

    • BASF Aktiengesellschaft Patent: US4189592 A1, 1980 ;
  • Route3
    • 5-Methyl-1H-imidazole hydrochloride|CS-1661140
      23187-14-6
    • ~%
    • In-stock
      2-(((4-Methyl-1H-imidazol-5-yl)methyl)thio)ethanamine dihydrochloride|CS-0153441
      38603-72-4

    References

    • Nippon Shokubai Kagaku Kogyo Co., Ltd. Patent: US4916233 A1, 1990 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.75362
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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