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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-iodo-1-methoxybenzene

  • CAS No. 3824-21-3

  • Cat. No. CS-W006461
  • Purity≥97%
  • MDL No.MFCD00691526

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-iodo-1-methoxybenzene|CS-W006461

Structure of 3824-21-3

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General Information

  • CAS No. 3824-21-3
  • Cat. No. CS-W006461
  • Purity ≥97%
  • MDL No. MFCD00691526
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FIO
  • Molecular Weight 252.03
  • Synonym(s) Benzene, 2-fluoro-4-iodo-1-Methoxy-
  • SMILES COC1=CC=C(I)C=C1F

Description

2-Fluoro-4-iodo-1-methoxybenzene features a strategically positioned fluorine atom and iodine substituent on a methoxy-substituted benzene ring, enabling efficient cross-coupling transformations. This electron-deficient aryl halide integrates readily into Suzuki and Stille reactions, offering high functional group tolerance and predictable regiochemistry under standard conditions.

Application

2-Fluoro-4-iodo-1-methoxybenzene serves as a versatile building block in cross-coupling chemistry, enabling efficient construction of biaryl and heterocyclic scaffolds. The ortho-fluoro and meta-iodo substituents provide complementary reactivity for sequential functionalization, while the methoxy group enhances solubility and modulates electronic properties. Bench-stable and compatible with Pd-catalyzed reactions, it facilitates reliable synthesis of complex aryl architectures relevant to pharmaceutical and agrochemical development.

Synthesis

  • Route1

    References

    • Malysheva, Yulia B.; Combes, Sebastien; Fedorov, Alexey Yu.; Knochel, Paul; Gavryushin, Andrei E. Synlett, 2012 , vol. 23, # 8 p. 1205 - 1208

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   2.4389
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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