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CS-W001157 4
Total: USD 88.00

Metronidazole

  • CAS No. 443-48-1

  • Cat. No. CS-2358
  • Purity≥98%
  • MDL No.MFCD00009750

*For research and further manufacturing use only, not for direct human use.

Metronidazole|CS-2358

Structure of 443-48-1

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General Information

  • CAS No. 443-48-1
  • Cat. No. CS-2358
  • Purity ≥98%
  • MDL No. MFCD00009750
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃O₃
  • Molecular Weight None
  • Synonym(s) None
  • SMILES OCCN1C([N+]([O-])=O)=CN=C1C

Description

Nitroreduction in anaerobic microorganisms activates Metronidazole (CAS 443-48-1), generating cytotoxic radicals that fragment DNA and induce irreversible cell death in pathogenic protozoa and obligate anaerobes.

Application

Metronidazole (CAS 443-48-1) serves as a critical reference standard in laboratory testing, precisely defined within the European Pharmacopoeia for analytical validation. It ensures accurate quantification of nitroimidazole compounds. This standard enables reliable detection in microbial and pharmaceutical assays.

Synthesis

  • Route1

    References

    • Zeb, Aurang; Malik, Imran; Rasheed, Saima; Choudhary, Muhammad Iqbal; Basha, Fatima Z. Medicinal Chemistry, 2012 , vol. 8, # 5 p. 846 - 852
  • Route2
    • null|null
      75-21-8
    • 2-Methyl-5-nitroimidazole Tinidazole Impurity|CS-0229738
      696-23-1
    • ~%
    • In-stock
      Metronidazole|CS-2358
      443-48-1

    References

    • Kraft, M. Ya.; Kochergin, P. M.; Tsyganova, A. M.; Shlikhunova, V. S. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 10 p. 861 - 863 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 10 p. 1246 - 1248
  • Route3
    • Metronidazole Impurity 38|CS-1004671
      73334-05-1
    • ~%
    • In-stock
      Metronidazole|CS-2358
      443-48-1

    References

    • Cho; Kurtz; Lewis; Machkovech; Houser Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 4 p. 410 - 414

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H340-H350-H373
Precautionary Statements : P260-P280-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   81.19
  • LogP   0.09202
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   3

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