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CS-W001157 4
Total: USD 88.00

2-Bromo-N-(4-(trifluoromethyl)phenyl)acetamide

  • CAS No. 3823-19-6

  • Cat. No. CS-0603010
  • Purity≥97%
  • MDL No.MFCD00662747

*For research and further manufacturing use only, not for direct human use.

2-Bromo-N-(4-(trifluoromethyl)phenyl)acetamide|CS-0603010

Structure of 3823-19-6

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General Information

  • CAS No. 3823-19-6
  • Cat. No. CS-0603010
  • Purity ≥97%
  • MDL No. MFCD00662747
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇BrF₃NO
  • Molecular Weight 282.06
  • Synonym(s) None
  • SMILES C1=CC(=CC=C1C(F)(F)F)NC(=O)CBr

Description

2-Bromo-N-(4-(trifluoromethyl)phenyl)acetamide features a brominated acetyl group linked to a para-trifluoromethyl-substituted phenyl ring, delivering enhanced electron-withdrawing character and improved metabolic stability. This structure facilitates efficient coupling reactions in synthetic medicinal chemistry, particularly in the construction of bioactive heterocycles and pharmaceutical intermediates under standard conditions.

Application

2-Bromo-N-(4-(trifluoromethyl)phenyl)acetamide serves as a versatile building block in medicinal chemistry, enabling efficient access to biaryl-containing scaffolds via palladium-catalyzed cross-coupling reactions. The bromo group facilitates reliable Suzuki, Stille, and Negishi couplings, while the trifluoromethyl aryl moiety enhances metabolic stability and lipophilicity. Bench-stable and readily purified by recrystallization, it functions effectively in late-stage functionalization workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   3.0388
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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