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CS-W001157 4
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2-(5-Methylpyridin-2-yl)acetonitrile

  • CAS No. 38203-08-6

  • Cat. No. CS-0152868
  • Purity≥95%
  • MDL No.MFCD09923761

*For research and further manufacturing use only, not for direct human use.

2-(5-Methylpyridin-2-yl)acetonitrile|CS-0152868

Structure of 38203-08-6

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General Information

  • CAS No. 38203-08-6
  • Cat. No. CS-0152868
  • Purity ≥95%
  • MDL No. MFCD09923761
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂
  • Molecular Weight 132.16
  • Synonym(s) None
  • SMILES CC1=CN=C(C=C1)CC#N

Description

2-(5-Methylpyridin-2-yl)acetonitrile features a pyridine ring with a methyl group at the 5-position and a nitrile-bearing acetyl side chain, enabling integration into heterocyclic scaffolds. The electron-deficient pyridine ring pairs with the reactive nitrile moiety to facilitate coupling reactions under mild conditions. This compound serves as a key building block in medicinal chemistry for constructing bioactive molecules.

Application

2-(5-Methylpyridin-2-yl)acetonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of pyridine-containing heterocycles via standard functional group transformations. Its nitrile group facilitates nucleophilic addition and subsequent cyclization reactions, while the methyl-substituted pyridine moiety provides a stable, electron-deficient aromatic core. The compound exhibits excellent bench stability, mild reactivity profile, and compatibility with common coupling protocols, making it well-suited for modular synthesis workflows in API development.

Synthesis

  • Route1
    • (5-methylpyridin-2-yl)methyl acetate|CS-0014707
      772-71-4
    • ~%
    • In-stock
      2-(5-Methylpyridin-2-yl)acetonitrile|CS-0152868
      38203-08-6

    References

    • Arata; Achiwa Yakugaku Zasshi, 1959 ,  vol. 79, p. 108Chem.Abstr., 1959 , p. 10211            

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.4561
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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