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CS-W001157 4
Total: USD 88.00

4,7-Dichloro-2-methylquinazoline

  • CAS No. 38154-43-7

  • Cat. No. CS-0165835
  • Purity≥95%
  • MDL No.MFCD11044641

*For research and further manufacturing use only, not for direct human use.

4,7-Dichloro-2-methylquinazoline|CS-0165835

Structure of 38154-43-7

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General Information

  • CAS No. 38154-43-7
  • Cat. No. CS-0165835
  • Purity ≥95%
  • MDL No. MFCD11044641
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆Cl₂N₂
  • Molecular Weight 213.06
  • Synonym(s) QUINAZOLINE, 4,7-DICHLORO-2-METHYL-
  • SMILES CC1=NC(Cl)=C2C=CC(Cl)=CC2=N1

Description

4,7-Dichloro-2-methylquinazoline delivers a sterically accessible quinazoline core featuring electron-withdrawing chlorines at the 4 and 7 positions, enhancing electrophilicity for targeted couplings. The 2-methyl group provides steric protection and improves solubility, enabling reliable incorporation into pharmaceutical intermediates under standard conditions.

Application

4,7-Dichloro-2-methylquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of kinase inhibitor scaffolds. Its dichloro substitution pattern facilitates late-stage functionalization via palladium-catalyzed cross-coupling, while the methyl group provides a handle for further derivatization. The compound exhibits excellent bench stability and compatibility with standard reaction conditions, making it well-suited for modular synthesis workflows in API development.

Synthesis

  • Route1
    • 7-chloro-2-methylquinazolin-4(1H)-one|CS-0187262
      7012-88-6
    • ~67%
    • In-stock
      4,7-Dichloro-2-methylquinazoline|CS-0165835
      38154-43-7

    References

    • Fleming, William J.; Mueller-Bunz, Helge; Guiry, Patrick J. European Journal of Organic Chemistry, 2010 , # 31 p. 5996 - 6004
  • Route2

    References

    • Fleming, William J.; Mueller-Bunz, Helge; Guiry, Patrick J. European Journal of Organic Chemistry, 2010 , # 31 p. 5996 - 6004
  • Route3
    • null|null
      7033-57-0
    • ~%
    • In-stock
      4,7-Dichloro-2-methylquinazoline|CS-0165835
      38154-43-7

    References

    • Fleming, William J.; Mueller-Bunz, Helge; Guiry, Patrick J. European Journal of Organic Chemistry, 2010 , # 31 p. 5996 - 6004

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   3.24502
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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