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CS-W001157 4
Total: USD 88.00

2-Chloro-6-hydroxynicotinic acid

  • CAS No. 38025-90-0

  • Cat. No. CS-W008439
  • Purity≥95%
  • MDL No.MFCD18384896

*For research and further manufacturing use only, not for direct human use.

2-Chloro-6-hydroxynicotinic acid|CS-W008439

Structure of 38025-90-0

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General Information

  • CAS No. 38025-90-0
  • Cat. No. CS-W008439
  • Purity ≥95%
  • MDL No. MFCD18384896
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClNO₃
  • Molecular Weight 173.55
  • Synonym(s) 3-pyridinecarboxylic acid, 2-chloro-6-hydroxy-
  • SMILES ClC1=C(C(=O)O)C=CC(=N1)O

Description

2-Chloro-6-hydroxynicotinic acid features a strategically positioned chloro group and hydroxyl moiety on the nicotinic acid scaffold, enabling selective functionalization in medicinal chemistry. This electron-deficient heterocycle integrates readily into bioactive scaffolds, offering enhanced solubility and metabolic stability under standard conditions.

Application

2-Chloro-6-hydroxynicotinic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C6 position via nucleophilic substitution or oxidation. Its ortho-chloro and meta-hydroxyl groups provide orthogonal reactivity for late-stage derivatization. The compound exhibits bench stability, facilitates straightforward purification, and functions effectively in standard coupling protocols for heterocyclic scaffold construction.

Synthesis

  • Route1

    References

    • WO2010/108652 A1, ; Page/Page column 97 ; WO 2010/108652 A1
  • Route2

    References

    • US2005/256123 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   70.42
  • LogP   1.1388
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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