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CS-W001157 4
Total: USD 88.00

6-Hydroxypyridazine-3-carboxylic acid

  • CAS No. 37972-69-3

  • Cat. No. CS-W005425
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Hydroxypyridazine-3-carboxylic acid|CS-W005425

Structure of 37972-69-3

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General Information

  • CAS No. 37972-69-3
  • Cat. No. CS-W005425
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄N₂O₃
  • Molecular Weight 140.10
  • Synonym(s) 6-oxo-1,6-dihydropyridazine-3-carboxylic acid hydrate
  • SMILES O=C(C1=NN=C(O)C=C1)O

Description

Nitrendipine modulates NMDA receptor channel function in mammalian neurons. Nitrendipine has been shown to inhibit neutrophil adhesion to vascular endothelium. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.

Application

6-Hydroxypyridazine-3-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyridazine-based scaffolds through established coupling and functionalization protocols. Its dual functionality—phenolic hydroxyl and carboxylic acid—facilitates orthogonal derivatization, while its bench stability supports reliable handling in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Liang, Lei; Yang, Guanyu; Xu, Fengrong; Niu, Yan; Sun, Qi; Xu, Ping European Journal of Organic Chemistry, 2013 , # 27 p. 6130 - 6136
  • Route2

    References

    • Homer et al. Journal of the Chemical Society, 1948 , p. 2191,2194 Full Text Show Details Libermann; Rouaix Bulletin de la Societe Chimique de France, 1959 , p. 1793,1796
  • Route3

    References

    • Homer et al. Journal of the Chemical Society, 1948 , p. 2191,2194

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   83.31
  • LogP   -0.1196
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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