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CS-W001157 4
Total: USD 88.00

1,3,4-Oxadiazol-2-amine

  • CAS No. 3775-60-8

  • Cat. No. CS-0072489
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,3,4-Oxadiazol-2-amine|CS-0072489

Structure of 3775-60-8

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General Information

  • CAS No. 3775-60-8
  • Cat. No. CS-0072489
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂H₃N₃O
  • Molecular Weight 85.06
  • Synonym(s) [1,3,4]Oxadiazol-2-ylamin
  • SMILES NC1=NN=CO1

Description

1,3,4-Oxadiazol-2-amine features a heterocyclic core with dual nitrogen and oxygen atoms, delivering enhanced stability and hydrogen-bonding capacity. This scaffold integrates readily into bioactive molecules, serving as a polar isostere for amides or carboxylic acids. Its bench-stable nature enables straightforward handling in synthetic workflows, supporting efficient access to pharmaceutical intermediates and functional materials.

Application

1,3,4-Oxadiazol-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its amine functionality facilitates direct derivatization and conjugation, while the oxadiazole core imparts metabolic stability and favorable pharmacokinetic properties. The compound exhibits bench stability and compatibility with common coupling reactions, making it well-suited for parallel synthesis campaigns and API development workflows.

Synthesis

  • Route1
    • null|null
      74949-72-7
    • null|null
      95-54-5
    • ~0%
    • In-stock
      1,3,4-Oxadiazol-2-amine|CS-0072489
      3775-60-8
    • In-stock
      2-Methyl-1H-benzo[d]imidazole|CS-W013410
      615-15-6
    • null|null
      79015-02-4

    References

    • Weise, Alfons; Westphal, Guenter; Rabe, Harald Zeitschrift fuer Chemie (Stuttgart, Germany), 1981 , vol. 21, # 6 p. 218 - 219
  • Route2
    • 2-Formylhydrazine-1-carbothioamide|CS-0306682
      2302-84-3
    • ~%
    • In-stock
      1,3,4-Oxadiazol-2-amine|CS-0072489
      3775-60-8

    References

    • Stolle; Fehrenbach Journal fuer Praktische Chemie (Leipzig), 1929 , vol. <2> 122, p. 306
  • Route3
    • 5-Amino-1,3,4-oxadiazole-2-carboxylic acid|CS-0079011
      4970-61-0
    • ~%
    • In-stock
      1,3,4-Oxadiazol-2-amine|CS-0072489
      3775-60-8

    References

    • Noto, Renato; Buscemi, Silvestre; Werber, Giuseppe; Spinelli, Domenico Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1449 - 1452

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.94
  • LogP   -0.3482
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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