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CS-W001157 4
Total: USD 88.00

N4-Acetylcytidine

  • CAS No. 3768-18-1

  • Cat. No. CS-0030784
  • Purity≥96%
  • MDL No.MFCD00006540

*For research and further manufacturing use only, not for direct human use.

N4-Acetylcytidine|CS-0030784

Structure of 3768-18-1

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General Information

  • CAS No. 3768-18-1
  • Cat. No. CS-0030784
  • Purity ≥96%
  • MDL No. MFCD00006540
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅N₃O₆
  • Molecular Weight 285.25
  • Synonym(s) None
  • SMILES O=C(N=C(NC(C)=O)C=C1)N1[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

Description

N4-Acetylcytidine features a protected cytidine scaffold with an acetyl group at the exocyclic amine, enhancing metabolic stability and reducing unwanted reactivity. This modification enables reliable incorporation into oligonucleotides for probing RNA structure and function without deamination risk. The acetyl moiety improves solubility and facilitates handling under standard biochemical conditions.

Synthesis

  • Route1
    • null|null
      108-24-7
    • In-stock
      Cytidine|CS-1989
      65-46-3
    • ~96%
    • In-stock
      N4-Acetylcytidine|CS-0030784
      3768-18-1

    References

    • Nahar, Pradip Tetrahedron Letters, 1997 , vol. 38, # 41 p. 7253 - 7254
  • Route2

    References

    • Xu, Yao-Zhong; Zheng, Qinguo; Swann, Peter F. Tetrahedron Letters, 1991 , vol. 32, # 24 p. 2817 - 2820
  • Route3
    • (2R,3R,4R,5R)-2-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-5-(acetoxymethyl)tetrahydrofuran-3,4-diyl diacetate Cytarabine Impurity|CS-0168212
      5040-18-6
    • ~76%
    • In-stock
      N4-Acetylcytidine|CS-0030784
      3768-18-1

    References

    • Kuboki, Atsuhito; Ishihara, Takashi; Kobayashi, Eiko; Ohta, Hiromichi; Ishii, Takeshi; Inoue, Ayumu; Mitsuda, Satoshi; Miyazaki, Tatsuo; Kajihara, Yasuhiro; Sugai, Takeshi Bioscience, Biotechnology and Biochemistry, 2000 , vol. 64, # 2 p. 363 - 368

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P341-P312-P330-P363-P501

Quality Control

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Computational Chemistry Data

  • TPSA   133.91
  • LogP   -2.1868
  • H_Acceptors   8
  • H_Donors   4
  • Rotatable_Bonds   3

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