Lot numbers can be found on the outside label of a product:
N4-Acetyl-2'-O-methylcytidine
-
CAS No. 113886-71-8
- Cat. No. CS-0172018
- Purity≥97%
- MDL No.MFCD15145149
*For research and further manufacturing use only, not for direct human use.
Structure of 113886-71-8
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 113886-71-8
- Cat. No. CS-0172018
- Purity ≥97%
- MDL No. MFCD15145149
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₂H₁₇N₃O₆
- Molecular Weight 299.28
- Synonym(s) None
- SMILES OC[C@@H]1[C@@H](O)[C@@H](OC)[C@H](N2C(N=C(NC(C)=O)C=C2)=O)O1
Description
N4-Acetyl-2'-O-methylcytidine features a cytidine scaffold with dual modifications: an acetyl group at the N4 position and a methyl ether at the 2' hydroxyl. This combination enhances metabolic stability and resistance to enzymatic degradation. The compound serves as a key building block for synthesizing modified oligonucleotides used in therapeutic and diagnostic applications.
Application
N4-Acetyl-2'-O-methylcytidine serves as a valuable nucleoside building block for the synthesis of modified RNA analogs, particularly in antisense oligonucleotide and siRNA development. Its N4-acetyl and 2'-O-methyl modifications enhance nuclease resistance and binding affinity, while maintaining compatibility with standard phosphoramidite coupling protocols. The compound exhibits excellent bench stability and facilitates efficient solid-phase synthesis, enabling precise incorporation of sterically hindered, bioactive motifs into therapeutic oligonucleotide sequences.
Synthesis
-
Route1
-
199593-14-1 - ~61%
-
In-stock
113886-71-8
References
-
Reddy; Hanna, Naeem B.; Farooqui, Firdous Nucleosides and Nucleotides, 1997 , vol. 16, # 7-9 p. 1589 - 1598
-
-
Route2
-
10212-28-9
- ~%
-
In-stock
113886-71-8
References
-
Beigelman, Leonid; Haeberli, Peter; Sweedler, David; Karpeisky, Alexander Tetrahedron, 2000 , vol. 56, # 8 p. 1047 - 1056
-
-
Route3
-
108-24-7
-
In-stock
2140-72-9 - ~%
-
In-stock
113886-71-8
References
-
Beigelman, Leonid; Haeberli, Peter; Sweedler, David; Karpeisky, Alexander Tetrahedron, 2000 , vol. 56, # 8 p. 1047 - 1056
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 122.91
- LogP -1.5327
- H_Acceptors 8
- H_Donors 3
- Rotatable_Bonds 4
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- N4-Acetyl-2'-O-methylcytidine sigmaN4-Acetyl-2'-O-methylcytidine manufacturerN4-Acetyl-2'-O-methylcytidine priceN4-Acetyl-2'-O-methylcytidine structureN4-Acetyl-2'-O-methylcytidine SDSbuy N4-Acetyl-2'-O-methylcytidineN4-Acetyl-2'-O-methylcytidine supplierN4-Acetyl-2'-O-methylcytidine usesN4-Acetyl-2'-O-methylcytidine molecular weightprice of N4-Acetyl-2'-O-methylcytidineN4-Acetyl-2'-O-methylcytidine chemical name formula of N4-Acetyl-2'-O-methylcytidine