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CS-W001157 4
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3-(Pyridin-3-yl)-1H-pyrazole-5-carboxylic acid

  • CAS No. 374064-01-4

  • Cat. No. CS-W005916
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Pyridin-3-yl)-1H-pyrazole-5-carboxylic acid|CS-W005916

Structure of 374064-01-4

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General Information

  • CAS No. 374064-01-4
  • Cat. No. CS-W005916
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇N₃O₂
  • Molecular Weight 189.17
  • Synonym(s) Acide 5-(3-pyridinyl)-1H-pyrazole-3-carboxylique
  • SMILES O=C(C1=CC(C2=CC=CN=C2)=NN1)O

Description

This pyrazole-based heterocycle integrates a pyridyl group and a carboxylic acid moiety, enabling direct conjugation in bioactive molecule design. The electron-deficient pyrazole core enhances reactivity in coupling reactions, while the carboxylic acid facilitates derivatization under standard conditions.

Application

3-(Pyridin-3-yl)-1H-pyrazole-5-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. Its pyrazole-carboxylic acid motif enables facile derivatization via amide coupling, esterification, or metal-catalyzed cross-coupling reactions. The molecule exhibits good bench stability and functional group tolerance, facilitating integration into complex scaffolds. Its structural rigidity and hydrogen-bonding capacity support target engagement in biological systems, making it valuable for scaffold hopping and lead optimization workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   78.87
  • LogP   1.1699
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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