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CS-W001157 4
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2-(Pyridin-2-yl)quinoline-4-carboxylic acid

  • CAS No. 57882-27-6

  • Cat. No. CS-0465888
  • Purity≥98%
  • MDL No.MFCD00224804

*For research and further manufacturing use only, not for direct human use.

2-(Pyridin-2-yl)quinoline-4-carboxylic acid|CS-0465888

Structure of 57882-27-6

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General Information

  • CAS No. 57882-27-6
  • Cat. No. CS-0465888
  • Purity ≥98%
  • MDL No. MFCD00224804
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₀N₂O₂
  • Molecular Weight 250.25
  • Synonym(s) 2-PYRIDIN-2-YL-QUINOLINE-4-CARBOXYLIC ACID
  • SMILES C1=CC=C2C(=C1)C(=CC(=N2)C3=CC=CC=N3)C(=O)O

Description

This pyridine-quinoline hybrid delivers a rigid, planar scaffold with dual nitrogen sites for metal coordination and hydrogen bonding. The carboxylic acid group enables conjugation and derivatization, while the electron-deficient quinoline core enhances π-stacking potential in supramolecular systems.

Application

2-(Pyridin-2-yl)quinoline-4-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. Its rigid, planar structure enables effective π-stacking interactions, while the carboxylic acid functionality facilitates direct coupling reactions or salt formation. The molecule exhibits good bench stability and moderate solubility in common organic solvents, supporting straightforward purification and integration into multi-step syntheses of kinase inhibitors, ligands, and functionalized scaffolds.

Synthesis

  • Route1

    References

    • Ricerca Scientifica, , vol. 28, p. 561,563 Iowa State College Journal of Science, , vol. 21, p. 44 Chem.Abstr., , p. 3045
  • Route2
    • 1-(Pyridin-2-yl)ethanone  Imatinib Impurity|CS-0167014
      1122-62-9
    • ~%
    • In-stock
      2-(Pyridin-2-yl)quinoline-4-carboxylic acid|CS-0465888
      57882-27-6

    References

    • Synthetic Communications, , vol. 27, # 12 p. 2165 - 2169
  • Route3

    References

    • Synthetic Communications, , vol. 27, # 12 p. 2165 - 2169

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   2.995
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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