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CS-W001157 4
Total: USD 88.00

5-Bromopyrazin-2-ol

  • CAS No. 374063-92-0

  • Cat. No. CS-W003277
  • Purity≥97%
  • MDL No.MFCD06245330
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromopyrazin-2-ol|CS-W003277

Structure of 374063-92-0

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Description

5-Bromopyrazin-2-ol delivers a reactive bromine handle at the 5-position of a pyrazinone scaffold, enabling facile cross-coupling and functionalization. The hydroxyl group at the 2-position provides hydrogen-bonding capacity and enhances solubility in polar media. This combination supports efficient incorporation into bioactive heterocycles and advanced synthetic intermediates under standard conditions.

Application

5-Bromopyrazin-2-ol serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo substituent and reactive hydroxyl group. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient construction of complex pyrazine-based scaffolds relevant to medicinal chemistry and agrochemical development.

General Information

  • CAS No. 374063-92-0
  • Cat. No. CS-W003277
  • Purity ≥97%
  • MDL No. MFCD06245330
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃BrN₂O
  • Molecular Weight 174.98
  • Synonym(s) 5-Bromo-2-pyrazinol
  • SMILES O=C1C=NC(Br)=CN1

Computational Chemistry Data

  • TPSA   45.75
  • LogP   0.5324
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group :
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P305+P351+P338-P330-P501

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