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CS-W001157 4
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2-(Pyridin-3-yl)acetamide

  • CAS No. 3724-16-1

  • Cat. No. CS-0008758
  • Purity≥97%
  • MDL No.MFCD08236789

*For research and further manufacturing use only, not for direct human use.

2-(Pyridin-3-yl)acetamide|CS-0008758

Structure of 3724-16-1

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General Information

  • CAS No. 3724-16-1
  • Cat. No. CS-0008758
  • Purity ≥97%
  • MDL No. MFCD08236789
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O
  • Molecular Weight 136.15
  • Synonym(s) 3-Pyridylacetamide; β-Pyridylethanamide; 3-Pyridineacetamide
  • SMILES NC(CC1=CC=CN=C1)=O

Description

2-(Pyridin-3-yl)acetamide features a pyridine ring directly linked to an acetamide group, delivering a robust scaffold for medicinal chemistry. The nitrogen-rich heterocycle enhances solubility and enables hydrogen bonding, while the amide moiety provides metabolic stability and directional polarity. This combination supports efficient integration into bioactive molecules, particularly in kinase inhibitors and CNS-targeted compounds.

Application

2-(Pyridin-3-yl)acetamide serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles through standard coupling and functionalization reactions. Its pyridine moiety provides favorable solubility and metabolic stability, while the amide group offers orthogonal reactivity for further derivatization. The compound exhibits excellent bench stability and is readily purified by standard chromatographic methods, making it well-suited for scalable synthesis and high-throughput screening workflows.

Synthesis

  • Route1

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2005/102997 A1, 2005 ; Location in patent: Page/Page column 51-52 ; WO 2005/102997 A1
  • Route2

    References

    • Burger; Walter Journal of the American Chemical Society, 1950 , vol. 72, p. 1988
  • Route3
    • 1-(Pyridin-3-yl)ethanone Imatinib Impurity|CS-0229620
      350-03-8
    • ~%
    • In-stock
      2-(Pyridin-3-yl)acetamide|CS-0008758
      3724-16-1

    References

    • Hartmann; Bosshard Helvetica Chimica Acta, 1941 , vol. 24, p. 28 E, 33 E

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   55.98
  • LogP   0.1094
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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