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CS-W001157 4
Total: USD 88.00

3-Methoxycarbonyl-4,6-dichloropyridazine

  • CAS No. 372118-01-9

  • Cat. No. CS-W008919
  • Purity≥98%
  • MDL No.MFCD09953612

*For research and further manufacturing use only, not for direct human use.

3-Methoxycarbonyl-4,6-dichloropyridazine|CS-W008919

Structure of 372118-01-9

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General Information

  • CAS No. 372118-01-9
  • Cat. No. CS-W008919
  • Purity ≥98%
  • MDL No. MFCD09953612
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄Cl₂N₂O₂
  • Molecular Weight 207.01
  • Synonym(s) 4,6-Dichloropyridazine-3-carboxylic acid methyl ester; Methyl 4,6-dichloropyridazine-3-carboxylate; METHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLAT
  • SMILES O=C(C1=NN=C(Cl)C=C1Cl)OC

Description

3-Methoxycarbonyl-4,6-dichloropyridazine features a pyridazine core bearing two chlorine substituents and a methoxycarbonyl group at the 3-position. This electron-deficient heterocycle integrates readily into synthetic routes requiring orthogonal reactivity, enabling selective coupling under mild conditions. The molecule exhibits enhanced stability and solubility in common organic solvents, facilitating use in pharmaceutical intermediates and agrochemical development.

Application

3-Methoxycarbonyl-4,6-dichloropyridazine serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyridazinone scaffolds via nucleophilic displacement or hydrolysis. The dichloro substitution pattern facilitates sequential functionalization, while the methoxycarbonyl group provides a handle for further derivatization. Bench-stable and compatible with standard coupling conditions, it supports scalable routes in medicinal chemistry and agrochemical research.

Synthesis

  • Route1

    References

    • US2013/178478 A1, ; Paragraph 0301;0302 ;
  • Route2

    References

    • US2013/178478 A1, ;
  • Route3
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      83878-89-1
    • ~%
    • In-stock
      3-Methoxycarbonyl-4,6-dichloropyridazine|CS-W008919
      372118-01-9

    References

    • US2013/178478 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.08
  • LogP   1.57
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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