Methyl 4,6-dihydroxypyridazine-3-carboxylate

Name: Methyl 4,6-dihydroxypyridazine-3-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 372118-00-8
Cat. No. CS-0106074
Molecule weight170.12
Purity≥97%
MDL No.MFCD09953611

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Methyl 4,6-dihydroxypyridazine-3-carboxylate|CS-0106074

Structure of 372118-00-8

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General Information

CAS No. 372118-00-8
Cat. No. CS-0106074
Purity ≥97%
MDL No. MFCD09953611
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆N₂O₄
Molecular Weight 170.12
Synonym(s) 3-Pyridazinecarboxylicacid,1,6-dihydro-4-hydroxy-6-oxo-,methylester(9CI)
SMILES O=C(C(C(O)=C1)=NNC1=O)OC

Description

Methyl 4,6-dihydroxypyridazine-3-carboxylate features a pyridazine core bearing two hydroxyl groups and a methyl ester, enabling versatile functionalization. This bench-stable scaffold integrates readily into synthetic sequences requiring electron-rich heterocycles with orthogonal reactivity.

Application

Methyl 4,6-dihydroxypyridazine-3-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyridazine-based scaffolds through selective derivatization. The ortho-diols facilitate controlled protection and functionalization, while the ester group supports cross-coupling and reduction reactions. Its bench-stable nature and compatibility with common purification methods make it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

Route1
- 83878-89-1
- ~30%
- In-stock
  
  372118-00-8
References
- Hoffman-La Roche Inc.; Hermann, Johannes Cornelius; Kennedy-Smith, Joshua; Lucas, Matthew C.; Padilla, Fernando; Soth, Michael Patent: US2013/178478 A1, 2013 ; Location in patent: Paragraph 0299;0300 ;
Route2
- In-stock
  
  1830-54-2
- ~%
- In-stock
  
  372118-00-8
References
- Hoffman-La Roche Inc.; Hermann, Johannes Cornelius; Kennedy-Smith, Joshua; Lucas, Matthew C.; Padilla, Fernando; Soth, Michael Patent: US2013/178478 A1, 2013 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 92.28
LogP -0.7379
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridazine compounds

Key Words

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Methyl 4,6-dihydroxypyridazine-3-carboxylate

CAS No. 372118-00-8

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