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CS-W001157 4
Total: USD 88.00

Fmoc-Cpa-OH

  • CAS No. 371770-32-0

  • Cat. No. CS-W022723
  • Purity≥97%
  • MDL No.MFCD03094886

*For research and further manufacturing use only, not for direct human use.

Fmoc-Cpa-OH|CS-W022723

Structure of 371770-32-0

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General Information

  • CAS No. 371770-32-0
  • Cat. No. CS-W022723
  • Purity ≥97%
  • MDL No. MFCD03094886
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₂₅NO₄
  • Molecular Weight 379.45
  • Synonym(s) None
  • SMILES O=C(O)[C@@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CC4CCCC4

Description

Fmoc-Cpa-OH is a bench-stable, moisture-tolerant amino acid derivative featuring a fluorenylmethoxy carbonyl (Fmoc) protecting group and a carboxylic acid handle. This combination enables efficient coupling in solid-phase peptide synthesis, offering reliable activation and minimal racemization during chain elongation.

Application

Fmoc-Cpa-OH serves as a robust building block in peptide synthesis, enabling efficient incorporation of cyclopropylalanine residues. The Fmoc group provides orthogonal protection for amines, allowing selective coupling under standard conditions. Its cyclopropyl side chain imparts conformational rigidity and enhanced metabolic stability, making it valuable for peptidomimetic and bioactive molecule design. The compound exhibits excellent bench stability, minimal epimerization risk, and straightforward purification via standard chromatographic methods.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   4.5586
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   6

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