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CS-W001157 4
Total: USD 88.00

4-Methyl-N-tosylbenzenesulfonamide

  • CAS No. 3695-00-9

  • Cat. No. CS-0145879
  • Purity≥98%
  • MDL No.MFCD00014917

*For research and further manufacturing use only, not for direct human use.

4-Methyl-N-tosylbenzenesulfonamide|CS-0145879

Structure of 3695-00-9

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General Information

  • CAS No. 3695-00-9
  • Cat. No. CS-0145879
  • Purity ≥98%
  • MDL No. MFCD00014917
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₅NO₄S₂
  • Molecular Weight 325.40
  • Synonym(s) Ditosylamine
  • SMILES O=S(C1=CC=C(C)C=C1)(NS(=O)(C2=CC=C(C)C=C2)=O)=O

Description

4-Methyl-N-tosylbenzenesulfonamide features a methyl-substituted aromatic ring paired with a tosyl group, delivering enhanced solubility and stability in organic synthesis. This bench-stable sulfonamide integrates readily into complex molecular architectures, serving as a robust scaffold for medicinal chemistry applications.

Application

4-Methyl-N-tosylbenzenesulfonamide serves as a stable, bench-ready sulfonamide building block for medicinal chemistry and heterocyclic synthesis. Its tosyl group enables efficient nucleophilic displacement and facilitates C–N bond formation in cross-coupling reactions. The methyl substituent enhances solubility and modulates electronic properties, while the robust sulfonamide functionality withstands standard reaction conditions. This compound functions effectively in the construction of biologically relevant scaffolds and supports orthogonal protection strategies in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   80.31
  • LogP   1.97064
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   4

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