Lot numbers can be found on the outside label of a product:
1-(4-Fluoro-3-methylphenyl)ethanone
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CAS No. 369-32-4
- Cat. No. CS-W018095
- Purity≥96%
- MDL No.MFCD04972879
*For research and further manufacturing use only, not for direct human use.
Structure of 369-32-4
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General Information
- CAS No. 369-32-4
- Cat. No. CS-W018095
- Purity ≥96%
- MDL No. MFCD04972879
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₉FO
- Molecular Weight 152.17
- Synonym(s) 4'-Fluoro-3'-methylacetophenone
- SMILES C1=C(C(=CC=C1C(=O)C)F)C
Description
1-(4-Fluoro-3-methylphenyl)ethanone features a fluorinated aromatic ring with a methyl substituent at the meta position, paired with a ketone-functionalized ethyl side chain. This configuration imparts enhanced lipophilicity and metabolic stability, enabling its use in medicinal chemistry scaffolds. The compound serves as a key intermediate for synthesizing bioactive molecules requiring electron-deficient aryl motifs.
Application
1-(4-Fluoro-3-methylphenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient access to biologically relevant aryl ketones. Its fluorinated aromatic core enhances metabolic stability and modulates electronic properties, while the acetyl group facilitates downstream transformations such as reduction, nucleophilic addition, and coupling reactions. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step syntheses of pharmaceutical intermediates and functionalized heterocycles.
Synthesis
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Route1
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181827-49-6 - ~94%
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In-stock
369-32-4
References
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Bomben, Andrea; Marques, Carlos A.; Selva, Maurizio; Tundo, Pietro Synthesis, 1996 , # 9 p. 1109 - 1114
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Route2
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95-52-3
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75-36-5
- ~79%
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In-stock
369-32-4
References
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Matulenko, Mark A.; Lee, Chih-Hung; Jiang, Meiqun; Frey, Robin R.; Cowart, Marlon D.; Bayburt, Erol K.; DiDomenico Jr., Stanley; Gfesser, Gregory A.; Gomtsyan, Arthur; Guo, Zhu Zheng; McKie, Jeffery A.; Stewart, Andrew O.; Yu, Haixia; Kohlhaas, Kathy L.; Alexander, Karen M.; McGaraughty, Steve; Wismer, Carol T.; Mikusa, Joseph; Marsh, Kennan C.; Snyder, Ronald D.; Diehl, Marilyn S.; Kowaluk, Elizabeth A.; Jarvis, Michael F.; Bhagwat, Shripad S. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 11 p. 3705 - 3720
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Route3
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In-stock
452-75-5 - ~%
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In-stock
369-32-4
References
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Bomben, Andrea; Marques, Carlos A.; Selva, Maurizio; Tundo, Pietro Synthesis, 1996 , # 9 p. 1109 - 1114
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 17.07
- LogP 2.33672
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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