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CS-W001157 4
Total: USD 88.00

1-(4-Fluoro-3-methylphenyl)ethanone,98%

  • CAS No. 369-32-4

  • Cat. No. CS-0898457
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(4-Fluoro-3-methylphenyl)ethanone,98%|CS-0898457

Structure of 369-32-4

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General Information

  • CAS No. 369-32-4
  • Cat. No. CS-0898457
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉FO
  • Molecular Weight 152.17
  • Synonym(s) 4'-Fluoro-3'-methylacetophenone,98%
  • SMILES CC1=CC(C(C)=O)=CC=C1F

Description

1-(4-Fluoro-3-methylphenyl)ethanone is a bench-stable ketone featuring a fluorinated aryl ring and a methyl-substituted ethyl group. This electron-deficient aromatic scaffold integrates readily into pharmaceutical intermediates, offering enhanced reactivity in nucleophilic addition and coupling reactions under standard conditions.

Application

1-(4-Fluoro-3-methylphenyl)ethanone serves as a versatile aryl ketone building block for medicinal chemistry and materials synthesis. Its fluorinated aromatic core enables enhanced metabolic stability and modulated electronic properties, while the acetyl group facilitates downstream transformations including nucleophilic additions, reductions, and coupling reactions. The compound exhibits excellent bench stability and is readily purified by recrystallization or column chromatography, making it well-suited for routine laboratory use in multi-step syntheses.

Synthesis

  • Route1
    • null|null
      181827-49-6
    • ~94%
    • In-stock
      1-(4-Fluoro-3-methylphenyl)ethanone,98%|CS-0898457
      369-32-4

    References

    • Bomben, Andrea; Marques, Carlos A.; Selva, Maurizio; Tundo, Pietro Synthesis, 1996 , # 9 p. 1109 - 1114
  • Route2
    • null|null
      95-52-3
    • null|null
      75-36-5
    • ~79%
    • In-stock
      1-(4-Fluoro-3-methylphenyl)ethanone,98%|CS-0898457
      369-32-4

    References

    • Matulenko, Mark A.; Lee, Chih-Hung; Jiang, Meiqun; Frey, Robin R.; Cowart, Marlon D.; Bayburt, Erol K.; DiDomenico Jr., Stanley; Gfesser, Gregory A.; Gomtsyan, Arthur; Guo, Zhu Zheng; McKie, Jeffery A.; Stewart, Andrew O.; Yu, Haixia; Kohlhaas, Kathy L.; Alexander, Karen M.; McGaraughty, Steve; Wismer, Carol T.; Mikusa, Joseph; Marsh, Kennan C.; Snyder, Ronald D.; Diehl, Marilyn S.; Kowaluk, Elizabeth A.; Jarvis, Michael F.; Bhagwat, Shripad S. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 11 p. 3705 - 3720
  • Route3

    References

    • Bomben, Andrea; Marques, Carlos A.; Selva, Maurizio; Tundo, Pietro Synthesis, 1996 , # 9 p. 1109 - 1114

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.33672
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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