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CS-W001157 4
Total: USD 88.00

5-(Trifluoromethyl)benzene-1,3-diamine

  • CAS No. 368-53-6

  • Cat. No. CS-W017415
  • Purity≥98%
  • MDL No.MFCD00014776

*For research and further manufacturing use only, not for direct human use.

5-(Trifluoromethyl)benzene-1,3-diamine|CS-W017415

Structure of 368-53-6

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General Information

  • CAS No. 368-53-6
  • Cat. No. CS-W017415
  • Purity ≥98%
  • MDL No. MFCD00014776
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇F₃N₂
  • Molecular Weight 176.14
  • Synonym(s) 5-Trifluoromethyl-1,3-phenylenediamine
  • SMILES NC1=CC(=CC(N)=C1)C(F)(F)F

Description

5-(Trifluoromethyl)-1,3-phenylenediamine was used in the synthesis of:hybrid materials based on new polyhedral oligomeric silsesquioxanefluorinated aromatic polyimide films

Application

5-(Trifluoromethyl)benzene-1,3-diamine serves as a valuable building block in medicinal chemistry and materials science, enabling the synthesis of heterocyclic scaffolds and functionalized aromatic systems. The ortho-diamine motif facilitates efficient cyclization reactions, while the trifluoromethyl group imparts enhanced metabolic stability and lipophilicity. Its bench-stable nature and compatibility with diverse coupling and condensation protocols make it a practical choice for multi-step syntheses and API development.

Synthesis

  • Route1
    • null|null
      401-99-0
    • ~99%
    • In-stock
      5-(Trifluoromethyl)benzene-1,3-diamine|CS-W017415
      368-53-6

    References

    • CHUGAI SEIYAKU KABUSHIKI KAISHA Patent: EP1724258 A1, 2006 ; Location in patent: Page/Page column 158 ;
  • Route2
    • null|null
      393-75-9
    • ~%
    • In-stock
      5-(Trifluoromethyl)benzene-1,3-diamine|CS-W017415
      368-53-6

    References

    • Occidental Chemical Corporation Patent: US5144076 A1, 1992 ;
  • Route3
    • null|null
      393-75-9
    • ~%
    • 2-Chloro-5-(trifluoromethyl)benzene-1,3-diamine|CS-0157698
      34207-44-8
    • In-stock
      5-(Trifluoromethyl)benzene-1,3-diamine|CS-W017415
      368-53-6

    References

    • Occidental Chemical Corporation Patent: US5347052 A1, 1994 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.04
  • LogP   1.8698
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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