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CS-W001157 4
Total: USD 88.00

4-(2,4-Difluorophenoxy)piperidine

  • CAS No. 367501-08-4

  • Cat. No. CS-0060352
  • Molecule weight213.22
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(2,4-Difluorophenoxy)piperidine|CS-0060352

Structure of 367501-08-4

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General Information

  • CAS No. 367501-08-4
  • Cat. No. CS-0060352
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₃F₂NO
  • Molecular Weight 213.22
  • Synonym(s) UKRORGSYN-BB BBV-084314
  • SMILES C1=CC(=C(C=C1F)F)OC2CCNCC2

Description

4-(2,4-Difluorophenoxy)piperidine features a fluorinated phenoxy linker that enhances metabolic stability and membrane permeability. This piperidine derivative integrates readily into bioactive scaffolds, serving as a key building block in medicinal chemistry for CNS-targeted compounds.

Application

4-(2,4-Difluorophenoxy)piperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard coupling and functionalization reactions. Its piperidine core provides a basic nitrogen for salt formation and hydrogen bonding, while the ortho- and para-fluorinated phenoxy moiety enhances metabolic stability and modulates lipophilicity. The compound exhibits good bench stability and facilitates efficient synthesis of targeted molecules via established amide, Suzuki, or Buchwald-Hartwig protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   2.0956
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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