Lot numbers can be found on the outside label of a product:
ICI-109081
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CAS No. 36725-28-7
- Cat. No. CS-W022429
- Purity≥97%
- MDL No.MFCD01692712
*For research and further manufacturing use only, not for direct human use.
Structure of 36725-28-7
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General Information
- CAS No. 36725-28-7
- Cat. No. CS-W022429
- Purity ≥97%
- MDL No. MFCD01692712
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₃N₃O
- Molecular Weight 203.24
- Synonym(s) None
- SMILES O=C1CC(C(C2=CC=C(C=C2)N)=NN1)C
Description
6-(4-Aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one features a fused heterocyclic core with a para-aminophenyl substituent and a methyl group at the 5-position. This electron-rich scaffold integrates readily into medicinal chemistry campaigns, offering a stable, bench-handling platform for targeted bioactive molecule design.
Application
6-(4-Aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one serves as a versatile building block for heterocyclic scaffolds in medicinal chemistry. Its pendant aniline and enolizable carbonyl functionalities enable diverse coupling reactions and downstream functionalization. The dihydropyridazinone core exhibits bench stability and facilitates purification, making it suitable for scalable synthesis of kinase inhibitors and other bioactive compounds.
Synthesis
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Route1
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101328-84-1 - ~%
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In-stock
36725-28-7
References
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WO2011/7123 A1, ; Page/Page column 12 ;
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Route2
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In-stock
120757-13-3 - ~99%
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In-stock
36725-28-7
References
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Wang, Teng; Dong, Ying; Wang, Li-Chen; Chen, Zhen Arzneimittel-Forschung/Drug Research, 2007 , vol. 57, # 10 p. 641 - 646
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Route3
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81937-39-5 - ~%
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In-stock
36725-28-7
References
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Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1689 - 1695
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 67.48
- LogP 1.1289
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 1
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Key Words
- ICI-109081 sigmaICI-109081 manufacturerICI-109081 priceICI-109081 structureICI-109081 SDSbuy ICI-109081ICI-109081 supplierICI-109081 usesICI-109081 molecular weightprice of ICI-109081ICI-109081 chemical name formula of ICI-109081