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Structure of 367-29-3
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5-Fluoro-2-methylaniline features a fluorine atom at the 5-position and a methyl group at the 2-position, creating a uniquely activated aromatic system. This electron-rich scaffold enables efficient coupling reactions in pharmaceutical synthesis, particularly in constructing substituted anilines for kinase inhibitors and bioactive heterocycles. The compound exhibits excellent stability under standard bench conditions and demonstrates favorable solubility in common organic solvents, streamlining its integration into multi-step synthetic sequences.
5-Fluoro-2-methylaniline serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via standard coupling reactions. Its ortho-methyl and meta-fluoro substituents provide directed functionalization opportunities and enhance metabolic stability in target molecules. The compound exhibits good bench stability and facilitates efficient derivatization under mild conditions, making it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H315-H319-H332-H335
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Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P304+P341-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P363-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: