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CS-W001157 4
Total: USD 88.00

4-Hydroxy-2,3-dihydroisoindol-1-one

  • CAS No. 366453-21-6

  • Cat. No. CS-W022188
  • Molecule weight149.15
  • Purity≥97%
  • MDL No.MFCD10000829

*For research and further manufacturing use only, not for direct human use.

4-Hydroxy-2,3-dihydroisoindol-1-one|CS-W022188

Structure of 366453-21-6

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General Information

  • CAS No. 366453-21-6
  • Cat. No. CS-W022188
  • Purity ≥97%
  • MDL No. MFCD10000829
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇NO₂
  • Molecular Weight 149.15
  • Synonym(s) 4-hydroxyisoindolin-1-one
  • SMILES OC1=CC=CC2=C1CNC2=O

Description

4-Hydroxy-2,3-dihydroisoindol-1-one features a unique fused heterocyclic scaffold with a labile hydroxyl group at the 4-position, enabling direct functionalization in synthetic transformations. This bench-stable, moisture-tolerant core integrates readily into bioactive molecule design, offering strategic access to complex nitrogen-containing architectures via C–H activation or coupling protocols.

Application

4-Hydroxy-2,3-dihydroisoindol-1-one serves as a versatile scaffold for medicinal chemistry and heterocyclic synthesis, offering a readily accessible platform for derivatization at the hydroxyl and carbonyl functionalities. Its stability under standard reaction conditions facilitates efficient functional group interconversions, enabling straightforward access to substituted isoindolinones and related bioactive frameworks commonly found in pharmaceutical development.

Synthesis

  • Route1

    References

    • Boehringer Ingelheim (Canada) Ltd. Patent: US2004/106791 A1, 2004 ; Location in patent: Page 9 ;
  • Route2
    • null|null
      1290140-09-8
    • ~94%
    • In-stock
      4-Hydroxy-2,3-dihydroisoindol-1-one|CS-W022188
      366453-21-6

    References

    • Lopez-Valdez, German; Olguin-Uribe, Simon; Millan-Ortiz, Alejandra; Gamez-Montano, Rocio; Miranda, Luis D. Tetrahedron, 2011 , vol. 67, # 14 p. 2693 - 2701
  • Route3
    • null|null
      1290140-07-6
    • ~%
    • In-stock
      4-Hydroxy-2,3-dihydroisoindol-1-one|CS-W022188
      366453-21-6

    References

    • Lopez-Valdez, German; Olguin-Uribe, Simon; Millan-Ortiz, Alejandra; Gamez-Montano, Rocio; Miranda, Luis D. Tetrahedron, 2011 , vol. 67, # 14 p. 2693 - 2701

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   0.6356
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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