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CS-W001157 4
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[(4-Methylphenyl)sulfonyl]methylformamide

  • CAS No. 36635-56-0

  • Cat. No. CS-0117120
  • Molecule weight213.25
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

[(4-Methylphenyl)sulfonyl]methylformamide|CS-0117120

Structure of 36635-56-0

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General Information

  • CAS No. 36635-56-0
  • Cat. No. CS-0117120
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₃S
  • Molecular Weight 213.25
  • Synonym(s) N-{[(4-methylphenyl)sulfonyl]methyl}formamide
  • SMILES O=CNCS(=O)(C1=CC=C(C)C=C1)=O

Description

This sulfonyl-containing formamide integrates a 4-methylphenyl group for enhanced stability and solubility in organic media. It serves as a versatile reagent in nucleophilic substitution reactions, enabling efficient functionalization at the methylformamide site under mild conditions.

Application

[(4-Methylphenyl)sulfonyl]methylformamide serves as a versatile sulfonamide-based formylating agent, enabling efficient introduction of the formyl group under mild conditions. It functions as a stable, bench-ready alternative to hazardous formylating reagents, exhibiting high chemoselectivity and compatibility with sensitive functional groups. Its utility extends to the synthesis of formylated heterocycles and peptide derivatives, facilitating key steps in medicinal chemistry and API development.

Synthesis

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      77287-34-4
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    • In-stock
      [(4-Methylphenyl)sulfonyl]methylformamide|CS-0117120
      36635-56-0

    References

    • Chen, Qingqi; Huggins, Michael T.; Lightner, David A.; Norona, Wilma; McDonagh, Antony F. Journal of the American Chemical Society, 1999 , vol. 121, # 40 p. 9253 - 9264
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      824-79-3
    • ~%
    • In-stock
      [(4-Methylphenyl)sulfonyl]methylformamide|CS-0117120
      36635-56-0

    References

    • US4922016 A1, ;
  • Route3
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      13052-19-2
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      824-79-3
    • ~%
    • In-stock
      [(4-Methylphenyl)sulfonyl]methylformamide|CS-0117120
      36635-56-0

    References

    • Justus Liebigs Annalen der Chemie, , vol. 766, p. 130 - 141

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.24
  • LogP   0.47222
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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