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CS-W001157 4
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2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid

  • CAS No. 3663-80-7

  • Cat. No. CS-W002348
  • Purity≥97%
  • MDL No.MFCD00084888

*For research and further manufacturing use only, not for direct human use.

2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid|CS-W002348

Structure of 3663-80-7

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General Information

  • CAS No. 3663-80-7
  • Cat. No. CS-W002348
  • Purity ≥97%
  • MDL No. MFCD00084888
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈O₄
  • Molecular Weight 180.16
  • Synonym(s) 1,4-Benzodioxane-2-carboxylic Acid
  • SMILES OC(C1COC2=CC=CC=C2O1)=O

Description

Acridine orange zinc chloride double salt (C.I. 46005 )for microscopy Certistain, is a dye it is chemically quality-certified according to highest standards and strict specifications.for microscopy Certistain

Application

2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid serves as a versatile scaffold for medicinal chemistry and synthetic organic applications. Its rigid, oxygenated bicyclic core provides structural stability and favorable pharmacokinetic properties. The carboxylic acid group enables direct derivatization via amide coupling, esterification, or decarboxylation protocols, facilitating integration into bioactive molecules. Bench-stable and compatible with standard purification methods, it functions as a key building block in the synthesis of heterocyclic APIs and functionalized intermediates.

Synthesis

  • Route1

    References

    • Rouf, Abdul; Gupta, Pankaj; Aga, Mushtaq A.; Kumar, Brijesh; Chaubey, Asha; Parshad, Rajinder; Taneja, Subhash C. Tetrahedron Asymmetry, 2012 , vol. 23, # 22-23 p. 1615 - 1623
  • Route2
    • 2-Cyano-1,4-benzodioxan|CS-0034639
      1008-92-0
    • ~98%
    • In-stock
      2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid|CS-W002348
      3663-80-7

    References

    • Tomiyama; Wakabayashi; Yokota Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 77, p. 5373

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.76
  • LogP   0.911
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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