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CS-W001157 4
Total: USD 88.00

3-(4-Fluorobenzoyl)propionic acid

  • CAS No. 366-77-8

  • Cat. No. CS-W010603
  • Purity≥98%
  • MDL No.MFCD00002793

*For research and further manufacturing use only, not for direct human use.

3-(4-Fluorobenzoyl)propionic acid|CS-W010603

Structure of 366-77-8

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General Information

  • CAS No. 366-77-8
  • Cat. No. CS-W010603
  • Purity ≥98%
  • MDL No. MFCD00002793
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉FO₃
  • Molecular Weight 196.18
  • Synonym(s) 3-(4'-FLUOROBENZOYL)PROPIONIC ACID
  • SMILES C1=C(C(CCC(O)=O)=O)C=CC(=C1)F

Description

Tos-PEG8-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Application

3-(4-Fluorobenzoyl)propionic acid serves as a versatile building block for pharmaceutical and agrochemical synthesis, enabling the construction of bioactive heterocycles and functionalized aromatic systems. Its well-defined reactivity profile facilitates efficient derivatization via esterification, amidation, and coupling reactions, while the fluorinated aryl moiety enhances metabolic stability and membrane permeability in downstream candidates. The compound exhibits excellent bench stability and straightforward purification, making it ideal for scalable laboratory workflows.

Synthesis

  • Route1
    • In-stock
      Succinic anhydride|CS-0011581
      108-30-5
    • null|null
      462-06-6
    • ~98%
    • In-stock
      3-(4-Fluorobenzoyl)propionic acid|CS-W010603
      366-77-8

    References

    • Jefford; Kohmoto; Jaggi; Timari; Rossier; Rudaz; Barbuzzi; Gerard; Burger; Kamalaprija; Mareda; Bernardinelli; Manzanares; Canfield; Fleck; Robinson; Peters Helvetica Chimica Acta, 1995 , vol. 78, # 3 p. 647 - 662
  • Route2
    • null|null
      88427-81-0
    • ~%
    • In-stock
      3-(4-Fluorobenzoyl)propionic acid|CS-W010603
      366-77-8

    References

    • Journal of Medicinal Chemistry, , vol. 27, # 9 p. 1099 - 1101
  • Route3
    • null|null
      86798-58-5
    • ~%
    • In-stock
      3-(4-Fluorobenzoyl)propionic acid|CS-W010603
      366-77-8

    References

    • Journal of Medicinal Chemistry, , vol. 27, # 9 p. 1099 - 1101

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.37
  • LogP   1.8732
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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