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1,3,5-Trichloro-2-fluorobenzene

  • CAS No. 36556-33-9

  • Cat. No. CS-0157723
  • Purity≥97%
  • MDL No.MFCD00060654

*For research and further manufacturing use only, not for direct human use.

1,3,5-Trichloro-2-fluorobenzene|CS-0157723

Structure of 36556-33-9

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General Information

  • CAS No. 36556-33-9
  • Cat. No. CS-0157723
  • Purity ≥97%
  • MDL No. MFCD00060654
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂Cl₃F
  • Molecular Weight 199.44
  • Synonym(s) 1,3,5-trichloro-2-fluoro-benzene
  • SMILES C1=C(C=C(C(=C1Cl)F)Cl)Cl

Description

1,3,5-Trichloro-2-fluorobenzene features a highly electron-deficient aromatic ring stabilized by orthogonal halogen substituents. This configuration enables selective electrophilic substitution and facilitates coupling reactions under mild conditions. The molecule exhibits excellent bench stability and compatibility with diverse synthetic workflows.

Application

1,3,5-Trichloro-2-fluorobenzene serves as a versatile electrophilic building block in aromatic substitution chemistry. Its orthogonal halogenation pattern enables sequential functionalization via palladium-catalyzed cross-coupling reactions. The fluorine atom enhances metabolic stability and modulates electronic properties, making it valuable for constructing bioactive heterocycles and pharmaceutical intermediates. Bench-stable and readily purified by distillation, it facilitates scalable synthesis of complex molecular architectures.

Synthesis

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    • In-stock
      1,3,5-Trichloro-2-fluorobenzene|CS-0157723
      36556-33-9

    References

    • Yoneda, Norihiko; Fukuhara, Tsuyoshi; Kikuchi, Tetsuo; Suzuki, Akira Synthetic Communications, 1989 , vol. 19, # 5and6 p. 865 - 872

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.7859
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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